Nontherapeutic Risk Factors of Different Grouped Stage IIIC Breast Cancer Patients’ Mortality: A Study of the US Surveillance, Epidemiology, and End Results Database
Yue Qiu, Hongye Chen, Yongjing Dai, Baoshi Bao, Lin Tian, Y Chen
Abstract
Objectives. Stage IIIC breast cancer, as a local advanced breast cancer, has a poor prognosis compared with that of early breast cancer. We further investigated the risk factors of mortality in stage IIIC primary breast cancer patients and their predictive value. Methods. We extracted data from the US Surveillance, Epidemiology, and End Results (SEER) database of female patients with stage IIIC primary breast cancer (n = 1673) from January 2011 to December 2015. Results. Hormone receptor negativity ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> and <math xmlns="http://www.w3.org/1998/Math/MathML" id="M2"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , respectively), aggressive molecular typing ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M3"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> and <math xmlns="http://www.w3.org/1998/Math/MathML" id="M4"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , respectively), high T stage ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M5"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> and <math xmlns="http://www.w3.org/1998/Math/MathML" id="M6"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , respectively), a high number of positive lymph nodes (≥14) ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M7"> <mi>P</mi> <mo>=</mo> <mn>0.005</mn> </math> and <math xmlns="http://www.w3.org/1998/Math/MathML" id="M8"> <mi>P</mi> <mo>=</mo> <mn>0.001</mn> </math> , respectively), and lymph node ratio (≥0.8148) ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M9"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> and <math xmlns="http://www.w3.org/1998/Math/MathML" id="M10"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , respectively) were associated with poor disease-specific survival. The indicators of disease-specific survival included estrogen receptor status, progesterone receptor status, molecular typing, T stage, number of positive lymph nodes, and lymph node ratio ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M11"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , <math xmlns="http://www.w3.org/1998/Math/MathML" id="M12"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , <math xmlns="http://www.w3.org/1998/Math/MathML" id="M13"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , <math xmlns="http://www.w3.org/1998/Math/MathML" id="M14"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , <math xmlns="http://www.w3.org/1998/Math/MathML" id="M15"> <mi>P</mi> <mo>=</mo> <mn>0.002</mn> </math> , and <math xmlns="http://www.w3.org/1998/Math/MathML" id="M16"> <mi>P</mi> <mo>≤</mo> <mn>0.001</mn> </math> , respectively). Conclusion. Hormone receptor negativity, aggressive molecular typing, high T stage, high number of positive lymph nodes, and lymph node ratio are poor prognostic factors patients with stage IIIC primary breast cancer. The efficient indicators of disease-specific survival include estrogen receptor status, progesterone receptor status, molecular typing, T stage, number of positive lymph nodes, and lymph node ratio.