Conjugation of RTHLVFFARK to human lysozyme creates a potent multifunctional modulator for Cu<sup>2+</sup>-mediated amyloid β-protein aggregation and cytotoxicity
Li Xi, Wenjuan Wang, Xiaoyan Dong, Yan Sun
Abstract
Conjugation of alkaline decapeptide (RTHLVFFARK) to lysozyme creates a potent multifunctional modulator (R-hLys) for Cu<sup>2+</sup>-mediated amyloid β-protein aggregation and cytotoxicity.
Topics & Concepts
CytotoxicityLysozymeAmyloid (mycology)BiophysicsAmyloid βMaterials scienceChemistryNanotechnologyCombinatorial chemistryBiochemistryIn vitroBiologyMedicinePathologyDiseaseInorganic chemistryAlzheimer's disease research and treatmentsComputational Drug Discovery MethodsPrion Diseases and Protein Misfolding