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Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

Chenjian Gu, Yang Wu, Huimin Guo, Yuanfei Zhu, Wei Xu, Yuyan Wang, Yu Zhou, Zhiping Sun, Xia Cai, Yutang Li, Jing Liu, Zhong Huang, Zhenghong Yuan, Rong Zhang, Qiang Deng, Di Qu, Youhua Xie

2020Science Bulletin58 citationsDOIOpen Access PDF

Topics & Concepts

VerteporfinProtoporphyrin IXVirologyPhotodynamic therapyCidofovirIn vitroPharmacologyMedicineChemistryVirusBiochemistryOrganic chemistryRetinalChoroidal neovascularizationSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesPARP inhibition in cancer therapy
Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2 | Litcius