Lipiodol Deposition and Washout in Primary and Metastatic Liver Tumors After Chemoembolization
Nariman Nezami, Johanna M. M. van Breugel, Menelaos Konstantinidis, Julius Chapiro, Lynn Jeanette Savic, Milena Miszczuk, Irvin Rexha, MingDe Lin, Kelvin Hong, Christos Georgiades
Abstract
BACKGROUND/AIM: Lipiodol is the key component of conventional trans-arterial chemoembolization. Our aim was to evaluate lipiodol deposition and washout rate after conventional trans-arterial chemoembolization in intrahepatic cholangiocarcinoma and hepatic metastases originating from neuroendocrine tumors and colorectal carcinoma. PATIENTS AND METHODS: ) was analyzed on non-contrast computed tomography imaging obtained within 24 h post conventional trans-arterial chemoembolization, and 40-220 days after conventional trans-arterial chemoembolization using volumetric image analysis software. Tumor response was assessed on contrast-enhanced magnetic resonance imaging 1 month after conventional trans-arterial chemoembolization. RESULTS: compared to smaller tumors (25.43 vs. 22.71 days). Lipiodol wash out half-life was 54.76 days (p<0.01) and 29.45 days (p<0.00001) for tumors with a contrast enhancement burden of 60% or more and less than 60%, respectively. A negative exponential relationship for lipiodol washout was observed in non-responders (p<0.00001). CONCLUSION: , tumors with baseline contrast enhancement burden of less than 60%, and non-responding target lesions.