Discovery of novel rigid analogs of 2-naphthol with potent anticancer activity through multi-target topoisomerase I & II and tyrosine kinase receptor EGFR & VEGFR-2 inhibition mechanism

Heba K. Abd El-Mawgoud, Ahmed M. Fouda, Mohammed A. A. El-Nassag, Ahmed A. Elhenawy, Mohammad Y. Alshahrani, Ahmed M. El‐Agrody

2022Chemico-Biological Interactions24 citationsDOI

Topics & Concepts

ChemistryKinaseTyrosine kinaseCell cultureReceptor tyrosine kinaseCell growthBiochemistryTopoisomeraseDocking (animal)EnzymeReceptorBiologyMedicineGeneticsNursingCancer therapeutics and mechanismsSynthesis and biological activityBioactive Compounds and Antitumor Agents

Discovery of novel rigid analogs of 2-naphthol with potent anticancer activity through multi-target topoisomerase I &amp; II and tyrosine kinase receptor EGFR &amp; VEGFR-2 inhibition mechanism

Topics & Concepts

Discovery of novel rigid analogs of 2-naphthol with potent anticancer activity through multi-target topoisomerase I & II and tyrosine kinase receptor EGFR & VEGFR-2 inhibition mechanism