Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions
Ahmed M. Shawky, Faisal A. Almalki, Hayat Ali Alzahrani, Ashraf N. Abdalla, Bahaa G. M. Youssif, Nashwa A. Ibrahim, Mohammed Gamal, Hany A.M. El-Sherief, Maha M. Abdel‐Fattah, Ahmed A. Hefny, Ahmed H. Abdelazeem, Ahmed M. Gouda
Topics & Concepts
ChemistrySmall moleculeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)StereochemistryCovalent bondMoleculeBiological activityCombinatorial chemistryCoronavirus disease 2019 (COVID-19)Computational biologyBiochemistryIn vitroOrganic chemistryInfectious disease (medical specialty)PathologyBiologyMedicineDiseaseComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchSynthesis and biological activity