Unveiling the interaction mechanism of alogliptin benzoate with human serum albumin: Insights from spectroscopy, microcalorimetry, and molecular docking and molecular dynamics analyses
Shuangshuang Zhang, Ruixue Gan, Ludan Zhao, Qiaomei Sun, Hongzhao Xiang, Xi Xiang, Gang Zhao, Hui Li
Topics & Concepts
ChemistryIsothermal titration calorimetryIsothermal microcalorimetryCircular dichroismHuman serum albuminMolecular dynamicsHydrogen bondBinding constantFluorescence spectroscopyvan der Waals forceProtein secondary structureHydrophobic effectCrystallographyFluorescencePhysical chemistryBinding siteComputational chemistryMoleculeEnthalpyChromatographyOrganic chemistryThermodynamicsBiochemistryQuantum mechanicsPhysicsProtein Interaction Studies and Fluorescence AnalysisAnalytical Chemistry and ChromatographyProtein purification and stability