Metformin and exercise effects on postprandial insulin sensitivity and glucose kinetics in pre-diabetic and diabetic adults
Alfonso Moreno‐Cabañas, Felix Morales‐Palomo, Laura Álvarez-Jiménez, Diego Mora‐Gonzalez, Juan F. Ortega, Ricardo Mora‐Rodríguez
Abstract
Metformin is the most prescribed oral antidiabetic medicine in the world but its mechanism of action and its interactions with exercise are not fully understood. Our stable isotope tracer data suggested that metformin reduces the rates of oral glucose entering the circulation (gut-liver effect). Exercise, in turn, tended to reduce postprandial insulin blood levels potentiating metformin improvements in insulin sensitivity. Thus, exercise potentiates metformin improvements in glycemic control and should be advised to metformin users.
Topics & Concepts
MetforminPostprandialMedicineGlycemicInternal medicineEndocrinologyDiabetes mellitusInsulinInsulin sensitivityInsulin resistanceMetabolism, Diabetes, and CancerDiet and metabolism studiesPancreatic function and diabetes