Exploration of cytotoxic potential and tubulin polymerization inhibition activity of <i>cis</i>-stilbene-1,2,3-triazole congeners
Darshana Bora, Khan Mehtab Samir, Anamika Sharma, Shrilekha Chilvery, Sapana Bansod, Stephy Elza John, Mursalim Ali Khan, Chandraiah Godugu, Nagula Shankaraiah
Abstract
To scrutinize cis -stilbene based molecules with potential anticancer and tubulin polymerization inhibition activity, a new series of cis -stilbene-1,2,3-triazole congeners was designed and synthesized via a click chemistry protocol.
Topics & Concepts
TubulinChemistryPolymerizationTriazoleClick chemistryCytotoxic T cellMicrotubuleStereochemistryCombinatorial chemistryOrganic chemistryBiochemistryIn vitroBiologyCell biologyPolymerClick Chemistry and ApplicationsSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds