Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage impeding type 2 immune programs
Manuel O. Jakob, Nele Sterczyk, Sotiria Boulekou, Patrycja M. Forster, Luisa Barleben, Nadra Alzain, Katja J. Jarick, Roksana M. Pirzgalska, Bruno Raposo, Karl Hansson, Elisabeth Nyström, Aurelia Gondrand, Miguel González-Acera, Pierre S. Leclère, Marlen S. Lapson, Sarah Poggenseier, Divija Deshpande, Laura Velleman, Tilman Breiderhoff, Max Brunkhorst, Anton M Schüle, Gabriela Maria Guerra, Pawel Durek, Mir‐Farzin Mashreghi, Anja A. Kühl, Coco Chu, Christoph Schneider, Carl Weidinger, Britta Siegmund, Thierry M. Nordmann, David Voehringer, Jay V. Patankar, Christoph Becker, George Birchenough, Henrique Veiga‐Fernandes, Francesca Ronchi, Marina Kolesnichenko, Andreas Diefenbach, Christoph S. N. Klose
Topics & Concepts
BiologyEnteric nervous systemImmune systemCell biologyStem cellInnate lymphoid cellImmunologyInnate immune systemHomeostasisRegulatorCellular differentiationNeuroepithelial cellVasoactive intestinal peptideIntestinal epitheliumInterleukin 22Lineage (genetic)ImmunityIntestinal mucosaCell typeGut floraSecretionGastrointestinal tractPhenotypeCentral nervous systemSignal transductionEpitheliumCytokineLymphatic systemNervous systemGastrointestinal motility and disordersIL-33, ST2, and ILC PathwaysCongenital gastrointestinal and neural anomalies