Memantine-Derived Schiff Bases as Transdermal Prodrug Candidates
Ana Oliveira, Victoria C. Romero Colmenares, Renata Diniz, Jennifer Tavares Jacon Freitas, Clara M. da Cruz, Eduardo Burgarelli Lages, Lucas Antônio Miranda Ferreira, Rafael P. Vieira, Heloísa Beraldo
Abstract
might be an effective strategy to obtain a prodrug candidate with increased lipophilicity, which would be able to passively cross biological barriers during transdermal delivery and might have applications in the treatment of Alzheimer's disease and other neurological disorders.
Topics & Concepts
ProdrugLipophilicityTransdermalSchiff baseSalicylaldehydeChemistryPyridoxalHydrochlorideMedicinal chemistryHydrolysisStereochemistryPharmacologyCombinatorial chemistryOrganic chemistryBiochemistryMedicineEnzymeComputational Drug Discovery MethodsSurfactants and Colloidal SystemsFree Radicals and Antioxidants