Use of Mendelian randomization to better understand and treat sepsis
James A. Russell, Nuala J. Meyer, Keith R. Walley
Abstract
Discovering novel therapies and defining the causal contribution of genes, proteins and lipids is challenging in sepsis, because sepsis is so heterogeneous; effective therapies in one patient may not be effective in another, explaining in part why sepsis trials have not been very successful.
Topics & Concepts
Mendelian randomizationSepsisMedicineIntensive care medicineConfoundingARDSDiseaseEpiphenomenonClinical trialBioinformaticsCausal inferencePhenotypePleiotropyGenetic variantsImmunologyGeneticsInternal medicineBiologyGenePathologyLungPhilosophyGenotypeEpistemologySepsis Diagnosis and TreatmentMetabolomics and Mass Spectrometry StudiesHyperglycemia and glycemic control in critically ill and hospitalized patients