Visible-Light-Mediated Decarboxylative Radical Addition Bifunctionalization Cascade for the Production of 1,4-Amino Alcohols
Qiao-Fei Bao, Ming Li, Yu Xia, Yu‐Zhao Wang, Zhao‐Zhao Zhou, Yong‐Min Liang
Abstract
A photocatalytic decarboxylative radical addition bifunctionalization cascade for the synthesis of functionalized alcohols is described. The catalytic cycle is completed through single-electron transfer. The advantages of this reaction are the commercially available materials, wide functional group compatibility, and mild conditions. Notably, some amino acids and bioactive carboxylic acids can provide corresponding products in moderate to good yields, reflecting the potential value in drug development.
Topics & Concepts
ChemistryCascadeCatalysisDecarboxylationCombinatorial chemistryPhotocatalysisCascade reactionOrganic chemistryChromatographyRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods