The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice
Hongbing Liu, Sylvia Hilliard, Elizabeth A. Kelly, Chao‐Hui Chen, Zubaida Saifudeen, Samir S. El‐Dahr
Abstract
However, in this context, SIX1 failed to maintain NPC stemness. At the chromatin level, EZH1 and EZH2 restricted accessibility to AP-1-binding motifs, and their absence promoted a regulatory landscape akin to differentiated and nonlineage cells. We conclude that EZH2 is required for NPC renewal potential and that tempering of the differentiation program requires cooperation of both EZH1 and EZH2.
Topics & Concepts
EZH2BiologyChromatinCell biologyProgenitor cellTranscription factorEpigeneticsHistone methyltransferaseCell fate determinationStem cellCancer researchGeneticsGeneRenal and related cancersRenal cell carcinoma treatmentEpigenetics and DNA Methylation