Direct asymmetric reductive amination of α-keto acetals: a platform for synthesizing diverse α-functionalized amines
Yongjie Shi, Jingxin Wang, Feifan Yang, Chenhan Wang, Xumu Zhang, Pauline Chiu, Qin Yin
Abstract
ruthenium-catalyzed direct asymmetric reductive amination. The α-amino acetal products are versatile and valuable platform molecules that can be converted to the corresponding α-amino acids, amino alcohols, and other derivatives by convenient transformations.
Topics & Concepts
Reductive aminationAminationChemistryAcetalRutheniumCombinatorial chemistryAmino acidOrganic chemistryCatalysisMoleculeBiochemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisAdvanced Synthetic Organic Chemistry