Intermittent hypoxia enhances shear-mediated dilation of the internal carotid artery in young adults
Erika Iwamoto, Brady E. Hanson, Joshua M. Bock, Darren P. Casey
Abstract
We explored the effects of cyclic intermittent hypoxia (IH) on shear-mediated dilation of the internal carotid artery (ICA), a potential index of cerebral endothelial function, in young adults. Cyclic IH increased blood flow and shear rate in the ICA and, as a result, increased shear-mediated dilation of the ICA. These data suggest that cyclic IH could potentially be applied as a nonpharmacological therapy to optimize cerebral vascular health.
Topics & Concepts
Internal carotid arteryHypoxia (environmental)CardiologyMedicineInternal medicineCarotid arteriesMiddle cerebral arteryCerebral circulationCerebral blood flowIntermittent hypoxiaAnesthesiaIschemiaChemistryOxygenOrganic chemistryObstructive sleep apneaCardiovascular Health and Disease PreventionCerebrovascular and Carotid Artery DiseasesHigh Altitude and Hypoxia