B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
Bingfei Yu, Yanyan Qi, Rui Li, Quanming Shi, Ansuman T. Satpathy, Howard Y. Chang
Abstract
atypical memory B cells (ABCs). XIST inactivation with TLR7 agonism suffices to promote isotype-switched ABCs. These results indicate cell-type-specific diversification and function for lncRNA-protein complexes and suggest expanded roles for XIST in sex-differences in biology and medicine.
Topics & Concepts
XISTBiologyX-inactivationChromatinTranscriptomeDNA methylationRNAGeneticsEpigeneticsX chromosomeLong non-coding RNAGeneCell biologyGene expressionCancer-related molecular mechanisms researchinterferon and immune responsesImmune Cell Function and Interaction