An approach towards individualized lower rate settings for pacemakers
Margaret Infeld, Robert Avram, Kramer Wahlberg, Daniel N. Silverman, Nicole Habel, Daniel L. Lustgarten, Mark J. Pletcher, Jeffrey E. Olgin, Gregory M. Marcus, Markus Meyer
Abstract
Key Findings▪Without evidence-based guidance, the pacemaker lower rate limit is typically left at 60 beats per minute, which is much lower than the average adult resting heart rate of 71–79 beats per minute based on large cohorts.▪While low heart rates are beneficial for patients with systolic dysfunction, pacing at a more physiologic heart rate may be a therapeutic target for patients with diastolic dysfunction or heart failure with a preserved ejection fraction (HFpEF).▪Using data from the Centers for Disease Control and Prevention growth charts, the National Health and Nutrition Examination Survey, and the Health-eHeart Study, we demonstrate a negative linear relationship between height and resting heart rate both during human growth and among healthy adult individuals.▪We derived a simple linear regression equation that defines the relationship between height and resting heart rate, which could be used in future studies to investigate a personalized pacemaker lower rate in patients with diastolic dysfunction or HFpEF. ▪Without evidence-based guidance, the pacemaker lower rate limit is typically left at 60 beats per minute, which is much lower than the average adult resting heart rate of 71–79 beats per minute based on large cohorts.▪While low heart rates are beneficial for patients with systolic dysfunction, pacing at a more physiologic heart rate may be a therapeutic target for patients with diastolic dysfunction or heart failure with a preserved ejection fraction (HFpEF).▪Using data from the Centers for Disease Control and Prevention growth charts, the National Health and Nutrition Examination Survey, and the Health-eHeart Study, we demonstrate a negative linear relationship between height and resting heart rate both during human growth and among healthy adult individuals.▪We derived a simple linear regression equation that defines the relationship between height and resting heart rate, which could be used in future studies to investigate a personalized pacemaker lower rate in patients with diastolic dysfunction or HFpEF.