Lessons in Organic Fluorescent Probe Discovery
Sachin Bhausaheb Wagh, Vladimir A. Maslivetc, James J. La Clair, Alexander Kornienko
Abstract
Fluorescent probes have gained profound use in biotechnology, drug discovery, medical diagnostics, molecular and cell biology. The development of methods for the translation of fluorophores into fluorescent probes continues to be a robust field for medicinal chemists and chemical biologists, alike. Access to new experimental designs has enabled molecular diversification and led to the identification of new approaches to probe discovery. This review provides a synopsis of the recent lessons in modern fluorescent probe discovery.
Topics & Concepts
Drug discoveryNanotechnologyComputational biologyFluorescenceBiologyChemistryBiochemical engineeringBioinformaticsEngineeringMaterials sciencePhysicsQuantum mechanicsClick Chemistry and ApplicationsMolecular Sensors and Ion DetectionSupramolecular Self-Assembly in Materials