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Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors

Joon Lee, Hermany Munguba, Vanessa A. Gutzeit, Deo R. Singh, Melanie Kristt, Jeremy S. Dittman, Joshua Levitz

2020Cell Reports28 citationsDOIOpen Access PDF

Abstract

(Cell Reports 31, 107605-1–107605-15.e1–e5; May 5, 2020) In the originally published version of this article, Deo R. Singh was mistakenly omitted from the author list. The corrected author list appears here. The authors regret the error. Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate ReceptorsLee et al.Cell ReportsMay 05, 2020In BriefLee et al. perform analysis of single-cell RNA sequencing data to reveal that metabotropic glutamate receptor (mGluR) subtypes exhibit highly overlapping expression in mouse cortical pyramidal neurons. Quantitative characterization of assembly propensities using fluorescence-based assays reveal high-efficiency heterodimerization across group-I, -II, and -III mGluRs. Full-Text PDF Open Access

Topics & Concepts

Metabotropic glutamate receptorMetabotropic glutamate receptor 1Metabotropic glutamate receptor 2Metabotropic glutamate receptor 6Metabotropic glutamate receptor 4Metabotropic glutamate receptor 5Metabotropic glutamate receptor 7RegretGlutamate receptorMetabotropic receptorMetabotropic glutamate receptor 3Computational biologyBiologyComputer scienceReceptorBiochemistryMachine learningSingle-cell and spatial transcriptomicsbioluminescence and chemiluminescence researchNeuroinflammation and Neurodegeneration Mechanisms
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