Photoredox/Cobalt Dual‐Catalyzed Decarboxylative Elimination of Carboxylic Acids: Development and Mechanistic Insight
Kaitie C. Cartwright, Ebbin Joseph, Chelsea G. Comadoll, Jon A. Tunge
Abstract
Recently, dual-catalytic strategies towards the decarboxylative elimination of carboxylic acids have gained attention. Our lab previously reported a photoredox/cobaloxime dual catalytic method that allows the synthesis of enamides and enecarbamates directly from N-acyl amino acids and avoids the use of any stoichiometric reagents. Further development, detailed herein, has improved upon this transformation's utility and further experimentation has provided new insights into the reaction mechanism. These new developments and insights are anticipated to aid in the expansion of photoredox/cobalt dual-catalytic systems.
Topics & Concepts
CatalysisReagentPhotoredox catalysisCobaltCombinatorial chemistryChemistryDual roleDual (grammatical number)Organic chemistryPhotocatalysisLiteratureArtAdvanced Photocatalysis TechniquesCO2 Reduction Techniques and CatalystsSulfur-Based Synthesis Techniques