The Role of Secretory Pathways in Candida albicans Pathogenesis
Christiane Rollenhagen, Sahil Mamtani, Dakota Ma, Reva Dixit, Susan K. Eszterhas, Samuel A. Lee
Abstract
Candida albicans is a fungus that is a commensal organism and a member of the normal human microbiota. It has the ability to transition into an opportunistic invasive pathogen. Attributes that support pathogenesis include secretion of virulence-associated proteins, hyphal formation, and biofilm formation. These processes are supported by secretion, as defined in the broad context of membrane trafficking. In this review, we examine the role of secretory pathways in Candida virulence, with a focus on the model opportunistic fungal pathogen, Candida albicans.
Topics & Concepts
Candida albicansSecretionVirulenceMicrobiologyBiofilmBiologyContext (archaeology)PathogenPathogenesisFungusSecretory proteinOrganismCorpus albicansHyphaFungal pathogenBacteriaImmunologyGeneGeneticsBiochemistryPaleontologyBotanyAntifungal resistance and susceptibilityFungal Infections and StudiesPeptidase Inhibition and Analysis