A GATA3 Targeting Nucleic Acid Nanocapsule for <i>In Vivo</i> Gene Regulation in Asthma
Tyler D. Gavitt, Alyssa K. Hartmann, Shraddha S. Sawant, Arlind B. Mara, Steven M. Szczepanek, Jessica L. Rouge
Abstract
using human Jurkat T cells, which express GATA3 under homeostatic conditions. Additionally, mice treated with DNAzyme-NANs during house dust mite (HDM)-induced asthma developed less severe allergic lung inflammation than HDM-only control mice, as measured by pulmonary eosinophilia. This study suggests that peptide cross-linked GATA3 DNAzyme-NANs may have the potential to decrease the severity of asthma symptoms in human patients, and development of this technology for human use warrants further investigation.
Topics & Concepts
Nucleic acidIn vivoAsthmaNanotechnologyChemistryBiologyImmunologyMaterials scienceBiochemistryGeneticsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryAntimicrobial Peptides and Activities