Photoredox-catalyzed trifluoromethylation of 2<i>H</i>-indazoles using TT-CF<sub>3</sub><sup>+</sup>OTf<sup>−</sup> in ionic liquids
Xin He, Zhicheng Chen, Xianghui Zhu, Hao Liu, Yanjie Chen, Zhizhong Sun, W. K. Chu
Abstract
a free-radical mechanism with a broad substrate range, excellent regioselectivity, and good functional group tolerance. Furthermore, the utility of this protocol was demonstrated by the synthesis of a highly selective ligand for estrogen receptor beta (ERβ) and the drug granisetron. The protocol provides a mild and environmentally friendly solution for trifluoromethylation reaction.
Topics & Concepts
TrifluoromethylationChemistryCatalysisCombinatorial chemistryRegioselectivityIonic bondingIonic liquidSubstrate (aquarium)Functional groupLigand (biochemistry)PhotochemistryOrganic chemistryTrifluoromethylReceptorIonAlkylPolymerOceanographyGeologyBiochemistryFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCyclopropane Reaction Mechanisms