PEGylation of recombinant human deoxyribonuclease I decreases its transport across lung epithelial cells and uptake by macrophages
Sohaib Mahri, Eléonore Hardy, Tobias Wilms, Herlinde De Keersmaecker, Kevin Braeckmans, Stefaan C. De Smedt, Cynthia Bosquillon, Rita Vanbever
Topics & Concepts
PEGylationIn vivoMucociliary clearanceCystic fibrosisPEG ratioLungChemistryIn vitroEndocytosisPolyethylene glycolPharmacologyCellMedicineBiochemistryBiologyInternal medicineEconomicsBiotechnologyFinanceCystic Fibrosis Research AdvancesInhalation and Respiratory Drug DeliveryRNA Interference and Gene Delivery