TRPM3 expression and control of glutamate release from primary vagal afferent neurons
Forrest J. Ragozzino, Rachel A. Arnold, Axel J. Fenwick, Timothy P. Riley, Jonathan E. M. Lindberg, BreeAnne Peterson, James H. Peters
Abstract
Vagal afferent signaling coordinates autonomic reflex function and informs associated behaviors. Thermosensitive transient receptor potential (TRP) channels detect temperature and nociceptive stimuli in somatosensory afferent neurons, however their role in vagal signaling remains less well understood. We report that the TRPM3 ion channel provides a major thermosensitive point of control over vagal signaling and synaptic transmission. We conclude that TRPM3 translates physiological changes in temperature to neurophysiological outputs and can serve as a cellular integrator in vagal afferent signaling.
Topics & Concepts
NeuroscienceNeurotransmissionSomatosensory systemNociceptionAfferentGlutamate receptorReflexNeurophysiologyVagus nerveReceptorChemistryBiologyMedicineStimulationInternal medicineIon Channels and ReceptorsHeart Rate Variability and Autonomic ControlOlfactory and Sensory Function Studies