Antimicrobial and Wound-Healing Activities of Graphene-Reinforced Electrospun Chitosan/Gelatin Nanofibrous Nanocomposite Scaffolds
Isra H. Ali, Amgad Ouf, Fatma Elshishiny, Mehmet Berat Taskin, Jie Song, Mingdong Dong, Menglin Chen, Rania Siam, Wael Mamdouh
Abstract
growth inhibition percents of 50 and 80%, respectively. The cell viability assay showed no cytotoxicity on human fibroblasts when cultured with either unreinforced or reinforced nanofibers. The cell migration was higher in the case of reinforced nanofibers when compared to the unreinforced nanofibers after 24 and 48 h, which is substantially associated with the great effect of the graphene nanosheets on the cell migration capability. Unreinforced and reinforced nanofibers showed cell migration results up to 93.69 and 97%, respectively, after 48 h.
Topics & Concepts
NanofiberGrapheneGelatinMaterials scienceChitosanNanocompositeElectrospinningComposite materialChemical engineeringNanotechnologyChemistryPolymerOrganic chemistryEngineeringElectrospun Nanofibers in Biomedical ApplicationsGraphene and Nanomaterials ApplicationsTissue Engineering and Regenerative Medicine