Copper-catalyzed one-pot synthesis of 2-(2,2,2-trifluoroethyl)-substituted benzofused heterocycles
Wei Wu, Beibei Luo, Yi You, Zhiqiang Weng
Abstract
A method for copper-catalyzed synthesis of 2-trifluoroethyl-substituted benzofurans and indoles from the reaction of salicylaldehyde/2-aminobenzaldehyde <italic>p</italic>-tosylhydrazones with 2-bromo-3,3,3-trifluoropropene has been developed.
Topics & Concepts
ChemistrySalicylaldehydeCatalysisCopperOrganic chemistryCombinatorial chemistryMedicinal chemistryPolymer chemistrySchiff baseFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods