SVEP1 is a human coronary artery disease locus that promotes atherosclerosis
In‐Hyuk Jung, Jared S. Elenbaas, Arturo Alisio, Katherine Santana, Erica P. Young, Chul Joo Kang, Puja Kachroo, Kory J. Lavine, Babak Razani, Robert P. Mecham, Nathan O. Stitziel
Abstract
variant p.D2702G. These effects ultimately drive inflammation and promote atherosclerosis. Together, our results suggest that VSMC-derived SVEP1 is a proatherogenic factor and support the concept that pharmacological inhibition of SVEP1 should protect against atherosclerosis in humans.
Topics & Concepts
Coronary artery diseaseMedicineCoronary atherosclerosisCardiologyDiseaseInternal medicineArteryATHEROSCLEROTIC VASCULAR DISEASEGalectins and Cancer BiologyRNA modifications and cancerProtein Tyrosine Phosphatases