Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions
Yingfeng Tu, Lin Zhao, Daniel D. Billadeau, Da Jia
Abstract
-Golgi network (TGN) diverts proteins and lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis and signaling. In recent years, significant advancements have been made in understanding this classical pathway, revealing new insights into multiple steps of vesicular trafficking as well as critical roles of ER-endosome contacts for endosomal trafficking. In this review, we summarize up-to-date knowledge about this trafficking pathway, in particular, mechanisms of cargo recognition at endosomes and vesicle tethering at the TGN, and contributions of ER-endosome contacts.
Topics & Concepts
EndosomeOrganelleCell biologyGolgi apparatusVesicleRetromerTransport proteinVesicular transport proteinMembrane contact siteBiologyVesicular Transport ProteinsChemistryMembrane proteinEndoplasmic reticulumBiochemistryIntegral membrane proteinMembraneVacuolar protein sortingIntracellularCellular transport and secretionRetinal Development and DisordersCalcium signaling and nucleotide metabolism