Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy
Nouf S. Al‐Numair, Abdulrahman Theyab, Faisal A. Alzahrani, Anwar Shams, Ibrahim O. Alanazi, Atif Abdulwahab A. Oyouni, Osama M. Al‐Amer, Charalampos Mavromatis, Islam M. Saadeldin, Wed A. Abdali, Yousef MohammedRabaa Hawsawi
Abstract
Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, there has been an evolving interest in utilizing nanobodies of camel origin as therapeutic tools against cancer. Nanotechnology uses nanobodies an emerging attractive field that provides promises to researchers in advancing different scientific sectors including medicine and oncology. Nanobodies are characteristically small-sized biologics featured with the ability for deep tissue penetration and dissemination and harbour high stability at high pH and temperatures. The current review highlights the potential use of nanobodies that are naturally secreted in camels' biological fluids, both milk and urine, in the development of nanotechnology-based therapy for treating different typesQuery of cancers and other diseases. Moreover, the role of nano proteomics in the invention of novel therapeutic agents specifically used for cancer intervention is also illustrated.