The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems
Morten Beck Rye, Sebastian Krossa, Martina Hall, Casper van Mourik, Tone F. Bathen, Finn Drabløs, May‐Britt Tessem, Helena Bertilsson
Abstract
and metallothioneins with zinc-binding properties not previously studied in the prostate, and the expression of these genes are reduced in more aggressive cancer lesions. However, the absence of signature enrichment in common prostate model systems can make it challenging to study these genes mechanistically.
Topics & Concepts
Prostate cancerProstateSpermineBiologyGeneSecretionTranscriptomeCancer researchCancerComputational biologyEndocrinologyGene expressionGeneticsBiochemistryEnzymeTrace Elements in HealthDrug Transport and Resistance MechanismsIron Metabolism and Disorders