METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications
Dongdong Jian, Ying Wang, Liguo Jian, Hao Tang, Lixin Rao, Ke Chen, Zhen Jia, Wanjun Zhang, Yiran Liu, Chen Xu, Xiwen Shen, Chuanyu Gao, Shuai Wang, Muwei Li
Abstract
A modification and inducing endothelial cell inflammatory response as well as atherosclerotic plaque formation. Decreased expression of METTL14 can inhibit endothelial inflammation and atherosclerosis development. Therefore, METTL14 may serve as a potential target for the clinical treatment of atherosclerosis.
Topics & Concepts
FOXO1Gene knockdownInflammationTranscription factorBiologyCell biologyCancer researchImmunologyGeneBiochemistryRNA modifications and cancerCancer-related molecular mechanisms researchCancer-related gene regulation