A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling
Chandrani Mondal, Majo J. Gacha-Garay, Kathryn A. Larkin, Rebecca C. Adikes, Julie S. Di Martino, C. H. Chien, Madison Fraser, Ireti Eni-Aganga, Esperanza Agulló-Pascual, Katarzyna Cialowicz, Umut Özbek, Alexandra Naba, Angelo Gaitas, Tian-Ming Fu, Srigokul Upadhyayula, Eric Betzig, David Q. Matus, Benjamin L. Martin, Jose Javier Bravo‐Cordero
Abstract
cells have increased Smad2 activation and TGF-β2 secretion, resulting in increased invasion and p27 levels to sustain quiescence. These findings identify srGAP1 as a mediator of a proliferative to invasive phenotypic switch in BC cells in vivo through a TGF-β2-mediated signaling axis.
Topics & Concepts
ExtravasationDownregulation and upregulationCancer researchZebrafishPhenotypeTransforming growth factorBiologyPopulationCell biologyCancer cellSecretionCancerImmunologyMedicineEndocrinologyGeneGeneticsBiochemistryEnvironmental healthCellular Mechanics and InteractionsHippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics