Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy
Bhupesh Goyal, Deepti Goyal
Abstract
on its dimerization and, thus, catalytic activity. We believe that the present review will stimulate research in this less explored yet quite significant area. The effect of the COVID-19 epidemic and the possibility of future CoV outbreaks strongly emphasize the urgent need for the design and development of potent antiviral agents against CoV infections.
Topics & Concepts
ProteaseCoronavirusChemistryVirologyVirusCysteine proteaseMutationCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Severe acute respiratory syndrome coronavirusBroad spectrumComputational biologyEnzymeBiologyBiochemistryGeneMedicineCombinatorial chemistryDiseaseInfectious disease (medical specialty)PathologySARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesCRISPR and Genetic Engineering