Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application
Tao Huang, Huda Salem AlSalem, Mona Saad Binkadem, Soha T. Al‐Goul, Attalla F. El‐kott, Abdulrahman A. Alsayegh, Ghawi J. Majdou, Gaber El‐Saber Batiha, Bikash Karmakar
Abstract
In this study, silver nanoparticles (Ag NPs) were decorated on the surface of magnetic nanoparticles in an eco-friendly pathway applying Mentha extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared Ag/Fe3O4nanocomposite were determined using several advanced techniques. Hence, our protocol is green and advantageous in terms of- i) biochemical modified biocompatible nanocomposite; ii) nanomaterial providing high surface area and larger number reactive sites; iii) very simplistic synthetic procedure; vi) very low load of metal in the composite and v) high yield in short time. In the medicinal part, the anticancer properties of Ag/Fe3O4 nanocomposite against lung cancer cell lines were determined. The free radical for the antioxidant effects was DPPH. The IC50 of Ag/Fe3O4 nanocomposite was 200 µg/ml in the antioxidant test. The IC50 of the Ag/Fe3O4 nanocomposite were 183, 176, 169, and 125 µg/mL against lung cancer (NCI-H661, NCI-H1975, NCI-H1573, and NCI-H1563) cell lines, respectively. In addition, the current study offer that Ag/Fe3O4 nanocomposite could be a new potential adjuvant chemopreventive and chemotherapeutic agent against cytotoxic cells.