Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na<sup>+</sup> channel in the mouse kidney
Bernhard N. Bohnert, Daniel Essigke, Andrea Janessa, Jonas C. Schneider, Matthias Wörn, M. Zaher Kalo, Mengyun Xiao, Lingsi Kong, Kingsley Omage, Jörg Hennenlotter, Bastian Amend, Andreas L. Birkenfeld, Ferruh Artunç
Abstract
This study demonstrates that murine experimental nephrotic syndrome leads to aprotinin-sensitive proteolytic activation of the epithelial Na + channel at both the α- and γ-subunit, most likely by urinary serine protease activity or proteasuria.
Topics & Concepts
AprotininNephrotic syndromeEpithelial sodium channelSerine proteaseProteolytic enzymesChemistryProteaseProtein subunitKidneyUrinary systemProteasesEndocrinologyInternal medicineMedicineBiochemistryEnzymeSodiumOrganic chemistryGeneIon Transport and Channel RegulationElectrolyte and hormonal disordersNeuroendocrine regulation and behavior