Spatial Transcriptome Uncovers the Mouse Lung Architectures and Functions
Yujia Jiang, Shijie Hao, Xi Chen, Mengnan Cheng, Jiangshan Xu, Chenghao Li, Huiwen Zheng, Giacomo Volpe, Ao Chen, Sha Liao, Chuanyu Liu, Longqi Liu, Xun Xu
Abstract
processes as well as pulmonary diseases, for example, studies on tumor-infiltrating myeloid cells in lung cancer (Zilionis et al., 2019), generation of pulmonary fibrosis (Wu et al., 2020), neonatal development (Scaffa et al., 2021) and injury repair (Leist et al., 2020). The recent development of novel state-of-the-art genomic technologies allows a deeper exploration of the lung functionally and structurally. A growing number of mouse-lung genomic datasets have been generated and have been paramount for illustrating fundamental transcriptomic changes at the tissue level (Angelidis et al.,