Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects
Inês Mahú, Andreia Barateiro, Eva Rial‐Pensado, Noelia Martínez‐Sánchez, Sandra H. Vaz, Pedro M. S. D. Cal, Benjamin Jenkins, Tiago Rodrigues, Carlos Cordeiro, Miguel F. Costa, Raquel Mendes, Elsa Seixas, Mafalda M.A. Pereira, Nadiya Kubasova, Vitka Gres, Imogen Morris, Carolina Temporão, Marta Olivares, Yolanda Sanz, Albert Koulman, Francisco Corzana, Ana M. Sebastião, Miguel López, Gonçalo J. L. Bernardes, Ana I. Domingos
Abstract
-adrenoceptor, protecting mice against obesity by increasing lipolysis and thermogenesis, coupled to higher heat dissipation, which acts as an energy sink to increase energy expenditure without altering food intake or locomotor activity. Thus, we provide proof-of-principle for a novel class of exclusively peripheral anti-obesity sympathofacilitators that are devoid of any cardiovascular and brain-related side effects.