Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
Seongkyun Lim, J. William Deaver, Megan E. Rosa‐Caldwell, David E. Lee, Francielly Morena da Silva, Ana Regina Cabrera, Eleanor R. Schrems, Landen W. Saling, Tyrone A. Washington, James D. Fluckey, Nicholas P. Greene
Abstract
We set to investigate the role of miR-16 in skeletal muscle during diet-induced insulin resistance. Our data provide novel evidence that the lack of miR-16 induced multiple aberrations in insulin sensitivity, muscle contractility, mitochondrial network health, and protein turnover in a sex-dependent manner. Interestingly, miR-16 deletion leads to insulin resistance in males and exacerbated glucose intolerance in females, suggesting different mechanisms of metabolic dysregulation with a lack of miR-16 between sexes.
Topics & Concepts
Insulin resistanceEndocrinologyContractilityInternal medicineSkeletal muscleInsulin sensitivityBiologyInsulinFunction (biology)MedicineCell biologyMicroRNA in disease regulationRNA Research and SplicingCircular RNAs in diseases