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Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity

Bahaa G. M. Youssif, Ahmed M. Gouda, Amr H. Moustafa, Antar A. Abdelhamid, Hesham A. M. Gomaa, Islam Kamal, Adel A. Marzouk

2021Journal of Molecular Structure56 citationsDOI

Topics & Concepts

ChemistryMoietyDocking (animal)StereochemistryImidazoleArylCombinatorial chemistryIn vitroOxadiazoleBiochemistryOrganic chemistryMedicineNursingAlkylMelanoma and MAPK PathwaysCytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling
Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity | Litcius