Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF
John O’Sullivan, Mengbo Li, Yen Chin Koay, Xiaosuo Wang, Giovanni Guglielmi, Francine Z. Marques, Shane Nanayakkara, Justin A. Mariani, Eugene Slaughter, David M. Kaye
Abstract
The authors conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.
Topics & Concepts
CardiologyMedicineInternal medicineHeart failure with preserved ejection fractionHemodynamicsHeart failureEjection fractionCardiovascular Function and Risk FactorsCardiovascular and exercise physiologyHeart Failure Treatment and Management