Zinc chloride-catalyzed Grignard addition reaction of aromatic nitriles
Manabu Hatano, Kisara Kuwano, Riho Asukai, Ayako Nagayoshi, Haruka Hoshihara, Tsubasa Hirata, Miho Umezawa, S Tsubaki, Takeshi Yoshikawa, Ken Sakata
Abstract
was more effective than using a stoichiometric amount of zinc(ii)ates. Possible transition states are proposed on the basis of the active zinc(ii)ate species, and DFT calculations were carried out to elucidate a plausible reaction mechanism.
Topics & Concepts
CatalysisChemistryGrignard reactionZincHydrolysisOrganic chemistryGrignard reagentChlorideReaction conditionsMedicinal chemistryReagentCoordination Chemistry and OrganometallicsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis