Lactate metabolic checkpoint in immuno-oncology: mechanisms and therapeutic implications
Zhe Wang, Zhifeng Gu, Wendi Mo, Haijun Zhang
Topics & Concepts
Immune systemTumor microenvironmentRegulatorEpigeneticsWarburg effectBiologyImmunotherapyCancer researchHistoneCancer immunotherapyMetabolic pathwayReprogrammingImmune checkpointFunction (biology)Cell biologySignal transductionCancer cellImmunityBiomarkerCancerCellular metabolismImmunologyInnate immune systemCell metabolismAcquired immune systemPD-L1Histone H3MetabolismCancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerPARP inhibition in cancer therapy