<i>Pf</i> SRPK1 Regulates Asexual Blood Stage Schizogony and Is Essential for Male Gamete Formation
Sudhir Kumar, Vinay Kumar Baranwal, Amanda S. Leeb, Meseret T. Haile, Kenza M. Z. Oualim, Nina Hertoghs, Ashley M. Vaughan, Stefan H. I. Kappe
Abstract
Plasmodium sexual stages represent a critical bottleneck in the parasite life cycle. Gametocytes taken up in an infectious blood meal by female anopheline mosquito get activated to form gametes and fuse to form short-lived zygotes, which transform into ookinetes to infect mosquitoes.
Topics & Concepts
SchizogonyZygoteGametocyteBiologyGameteMalariaPlasmodium (life cycle)WolbachiaBlood mealVirologyZoologyImmunologyParasite hostingGeneticsPlasmodium falciparumGeneHuman fertilizationComputer scienceWorld Wide WebEmbryogenesisMalaria Research and ControlInvertebrate Immune Response MechanismsTrypanosoma species research and implications