CD4+ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection
Jinsheng Wen, Ying-Ting Wang, Kristen Valentine, Rúbens Prince dos Santos Alves, Zhi-Gang Xu, José Ángel Regla-Nava, Annie Elong Ngono, Matthew P. Young, Luís Carlos de Souza Ferreira, Sujan Shresta
Abstract
T cells producing canonical Th1 cytokines can suppress ZIKV replication in an antibody-independent manner. These results may have important implications for increasing the efficacy and safety of DENV/ZIKV vaccines and for developing pan-flavivirus vaccines.
Topics & Concepts
Zika virusVirologyDengue virusFlavivirusBiologyDengue feverEpitopeImmunologyAntibody-dependent enhancementT cellAntibodyVirusImmune systemMosquito-borne diseases and controlViral Infections and VectorsMalaria Research and Control