Microbial Primer: Lipopolysaccharide – a remarkable component of the Gram-negative bacterial surface
Leah M. VanOtterloo, M. Stephen Trent
Abstract
Lipopolysaccharide (LPS) is a fundamental tripartite glycolipid found on the surface of nearly all Gram-negative bacteria. It acts as a protective shield for the bacterial cell and is a potent agonist of the innate immune system. This primer serves to introduce the basic properties of LPS, its function in bacterial physiology and pathogenicity, and its use as a therapeutic target.
Topics & Concepts
LipopolysaccharideInnate immune systemBacteriaMicrobiologyBacterial cell structureGlycolipidGram-negative bacteriaImmune systemBiologyFunction (biology)Primer (cosmetics)Lipid AChemistryCell biologyImmunologyEscherichia coliBiochemistryGeneticsGeneOrganic chemistryImmune Response and InflammationProbiotics and Fermented FoodsAntimicrobial Peptides and Activities