RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis
Yu Gao, Minjie Shen, Jose Gonzalez, Qiping Dong, Sudharsan Kannan, Johnson T. Hoang, Brian E. Eisinger, Jyotsna Pandey, Sahar Javadi, Qiang Chang, Daifeng Wang, Linda Overstreet‐Wadiche, Xinyu Zhao
Abstract
(γ-Aminobutyric acid B) receptor activation. Knocking down RGS6 abolishes running-enhanced neuronal maturation and hippocampal neurogenesis-dependent learning and anxiolytic effect. Our study provides a data resource showing genome-wide intrinsic molecular changes in adult-born hippocampal neurons that contribute to voluntary running-induced neurogenesis.
Topics & Concepts
NeurogenesisHippocampal formationBiologyNeuroscienceRegulator of G protein signalingHippocampusTurnoverCell biologySignal transductionManagementEconomicsG proteinGTPase-activating proteinNeurogenesis and neuroplasticity mechanismsAdipose Tissue and MetabolismGenetics and Neurodevelopmental Disorders