Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB–CD8+ memory T cells and accumulation of type 2 memory T cells
Marina Terekhova, Amanda Swain, Pavla Boháčová, Ekaterina Aladyeva, Laura Arthur, Anwesha Laha, Denis A. Mogilenko, Samantha Burdess, Vladimir Sukhov, Denis Kleverov, Barbora Echalar, Petr Tsurinov, Roman Chernyatchik, Kamila Husarcikova, Maxim N. Artyomov
Abstract
(Immunity 56, 2836–2854.e1–e9; December 12, 2023) The authors noticed that x axis text labels of Temra cells and NKT-like cells were inadvertently swapped in Figures 4F and 4H during the final figure formatting, and it has now been corrected. The corrected figure panel does not affect the conclusions. Additionally, in the gating strategy panel for NK, NKT-like, and T cells in Figure S5A, there was an unintentional swap of the x and y axes labels. The authors corrected the panel, with CD3:BV510 now on the x axis and CD56:BV570 now on the y axis. The authors apologize for any confusion or inconvenience this has caused. Figure 4Changes in composition of CD8+ T cells during healthy aging (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cellsTerekhova et al.ImmunityNovember 13, 2023In BriefTerekhova et al. perform single-cell RNA sequencing on >300 samples between 25 and 85 years to comprehensively profile immune changes throughout aging. This resource revealed 12 subpopulations that change with age, including increased type 2 memory CD4+ and CD8+ T cells and decreased NKG2C+GZMB−CD8+ memory population. Full-Text PDF Open Access