Nucleic acid amplification-free biosensor for sensitive and specific cfDNA detection based on CRISPR-Cas12a and single nanoparticle dark-field microscopy (DFM) imaging
Xianghui Li, Xiulin Yang, Zhipeng Pan, Shuangmu Zhuo, Zhenyu Lin, Jianxin Chen
Topics & Concepts
Detection limitBiosensorNucleic acidColloidal goldMicroscopyNanotechnologyMaterials scienceChemistryNanoparticleChromatographyBiochemistryPhysicsOpticsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionCRISPR and Genetic Engineering